Porphyromonas gingivalis 관련 치주질환과 알츠하이머성 치매 간의 기능적 상관관계 연구
Functional Relationship between Porphyromonas Gingivalis-driven Periodontal Disease and Alzheimer's Dementia
부가영, 이지혜, 최대솔, 곽혜원, 전다은, 강수은, 이민서, 박태영, 심현룡,
소속 상세정보
부가영 ( Boo Ka-Young ) - Pusan National University School of Dentistry Department of Dentistry
이지혜 ( Lee Ji-Hye ) - Pusan National University Korean Medicine Hospital Department of Internal Medicine of Korean Medicine
최대솔 ( Choi Dae-Sol ) - Pusan National University School of Dentistry Department of Dentistry
곽혜원 ( Gwak Hye-Won ) - Pusan National University School of Dentistry Department of Dentistry
전다은 ( Jeon Da-Eun ) - Pusan National University School of Dentistry Department of Dentistry
강수은 ( Kang Su-Eun ) - Pusan National University School of Dentistry Department of Dentistry
이민서 ( Lee Min-Seo ) - Pusan National University School of Dentistry Department of Dentistry
박태영 ( Park Tae-Young ) - Pusan National University School of Dentistry Department of Dentistry
심현룡 ( Shim Hyeon-Ryong ) - Pusan National University School of Dentistry Department of Dentistry
Abstract
Periodontitis, especially in its chronic form, is one of the leading causes of tooth loss, significantly affecting the quality of life in the modern era of aging society. Recent studies have revealed a potential correlation between periodontitis and various systemic diseases, including cardiovascular diseases and Alzheimer’s dementia (AD). With the body of epidemiologic evidence that links these separate disease entities, several lines of hypotheses have been postulated to provide mechanistic understandings that mostly comprises abnormal regulation of immunologic and inflammatory signaling. In this review, we revisit the experimental findings that describe virulence factors derived from Porphyromonas Gingivalis, including gingipains and lipopolysaccharides, as well as their roles in the pathophysiology of AD. In addition, we address potential immunologic challenges imposed by this bacterial pathogen contributing to progression of AD.
키워드
Periodontitis ; Porphyromonas Gingivalis ; Alzheimer’s dementia ; Gingipains ; Lipopolysaccharides
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